Introduction to OX40 (CD134) and OX40-Ligand
OX40 is a 50 Kd glycosylated type 1 transmembrane protein. 1-4. The extracellular N-terminal portion of OX40 is 191 amino acids, and contains three cysteine-rich domains (CRDs) of approximately 40 amino acids, which are characteristic of the TNFR superfamily.
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OX40 Promotes Effector T cell Expansion and Survival. The T cell response to any acute antigenic stimulation has three distinct phases: expansion, contraction ...
CD134
Protein
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Tumor necrosis factor receptor superfamily, member 4, also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. Wikipedia
OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on ...
An agonistic monoclonal antibody against receptor OX40 (CD134), with potential immunostimulatory activity. Mimicking the natural OX4 ligand (OX40L), ...
OX40 may act as negative regulator of Treg function, which indirectly boosts effector CD4+ T cells by relieving them from Treg cell-mediated suppression. OX40 ...
The only known ligands for OX40 and CD27 are OX40L (TNFSF4) and CD70 (TNFSF7), respectively. Both are type II transmembrane proteins and contain the conserved ...
OX40 is a TNF-receptor family member that is expressed primarily on activated CD4+ and CD8+ T cells (16–18). Preclinical cancer models have shown that anti-OX40 ...
OX40 is a type 1 transmembrane glycoprotein, reported nearly 30 years ago as a cell surface antigen expressed on activated T cells. Since its discovery, it has ...
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The OX-86 monoclonal antibody reacts with mouse OX-40 also known as CD134. OX-40 is a 50 kDa type I membrane glycoprotein and a member of the TNF receptor ...
An agonist Ab to OX40 promoted greater numbers of CD4 T cells to accumulate after the peak of a normal primary response and to survive with time as memory cells ...