Platelet factor 4 (PF4) is a highly cationic tetrameric protein that can be targeted by platelet-activating anti-PF4 antibodies of immunoglobulin G (IgG) class.
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Jan 21, 2022 · Platelet factor 4 (PF4) is a 70-amino acid protein that is stored in alpha granules of platelets and is released on platelet activation [1]. PF4 ...
Dec 8, 2020 · It is used to help establish a diagnosis of immune-mediated heparin-induced thrombocytopenia (HIT type II) when you have a low platelet count ( ...
Dec 8, 2023 · Anti–platelet factor 4 (PF4) antibodies are the underlying cause of the prothrombotic disorders heparin-induced thrombocytopenia (HIT) and ...
Apr 5, 2013 · The HIT immune response is unique. It is characterized by PF4/GAG specific antibodies that occur after only several days of heparin exposure.
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May 22, 2017 · Antibodies recognizing complexes of the chemokine platelet factor 4 (PF4/CXCL4) and polyanions (P) opsonize PF4-coated bacteria hereby ...
Platelet factor 4 (PF4, CXCL4) is a 7.8 kDa, 70-amino-acid protein. It is very abundant in platelet α-granules,59 and its levels are estimated at 12±5 ng/106 ...
Recognition of PF4-VWF complexes by heparin-induced ...
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Apr 9, 2020 · PF4 bound to VWF strings form antigenic complexes that are recognized by HIT antibodies. PF4-VWF-HIT antibody complexes enhance platelet ...
Platelet factor 4 (PF4, CXCL4) is a 7.8 kDa, 70-amino-acid protein. It is very abundant in platelet α-granules,59 and its levels are estimated at 12±5 ng/106 ...
Detection of IgG antibodies directed against heparin/platelet factor 4 complexes that are implicated in the pathogenesis of immune-mediated type II ...