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Apr 16, 2024 · Thrombospondin-1 (TSP1) plays an indirect role in collagen homeostasis through interactions with matrix metalloproteinases and transforming ...

Thrombospondin 1 is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix ...

Mar 29, 2021 · TSP1 regulates nitric oxide, activates latent TGFβ1, and interacts with receptors CD36 and CD47, to play an important role in cell metabolism.

Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays a role in endothelial ...

Oct 2, 2023 · TSP1-. Mice homozygous for this targeted mutation exhibit an increase in the number of circulating white blood cells with monocytes and ...

TSP-1 is a large glycoprotein secreted by various cells under stress conditions such as those found in ischemic injury. This protein engages several cell ...

TSP1 is a secreted protein that is released by activated platelets and is expressed by many cell types in response to stress or injury (Roberts, Miller, Rogers, ...

Thrombospondins are multimeric multidomain glycoproteins that function at cell surfaces and in the extracellular matrix milieu. They act as regulators of ...