OX40 is induced on the T cell surface a number of hours or days after recognition of antigen, and expression coincides with the appearance of OX40L on several cell types that can present antigen such as dendritic cells and B cells.
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OX40 Promotes Effector T cell Expansion and Survival. The T cell response to any acute antigenic stimulation has three distinct phases: expansion, contraction ...
CD134
Protein
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Tumor necrosis factor receptor superfamily, member 4, also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. Wikipedia
OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on ...
OX40 is a TNF-receptor family member that is expressed primarily on activated CD4+ and CD8+ T cells (16–18). Preclinical cancer models have shown that anti-OX40 ...
An agonistic monoclonal antibody against receptor OX40 (CD134), with potential immunostimulatory activity. Mimicking the natural OX4 ligand (OX40L), ...
OX40 may act as negative regulator of Treg function, which indirectly boosts effector CD4+ T cells by relieving them from Treg cell-mediated suppression. OX40 ...
The only known ligands for OX40 and CD27 are OX40L (TNFSF4) and CD70 (TNFSF7), respectively. Both are type II transmembrane proteins and contain the conserved ...
OX40 is a type 1 transmembrane glycoprotein, reported nearly 30 years ago as a cell surface antigen expressed on activated T cells. Since its discovery, it has ...
Jun 1, 2004 · Among these candidate molecules, OX40 is a promising therapeutic target for allergic, inflammatory and autoimmune diseases, as well as a target ...
OX40L is the ligand for OX40 and is stably expressed on many antigen-presenting cells such as DC2s macrophages, and activated B lymphocytes.